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Tau Shows Promise as Achilles’ Heel for Alzheimer’s

Alzheimer’s disease has long been characterized primarily by the buildup of two proteins in the brain – beta-amyloid and tau. Decades of focus on beta-amyloid has failed to significantly help patients. So researchers are...

Maternal Risk for Alzheimer’s Disease

Advanced age is the most significant risk factor for late-onset Alzheimer’s disease, and having a parent with the disease is the second. It is estimated that individuals with a first-degree relative with Alzheimer’s disease (AD)...

Researchers design proteins that can be utilized to combat Alzheimer’s

A team of researchers, led by NYU Abu Dhabi Assistant Professor of Biology Mazin Magzoub, has developed small proteins called cell-penetrating peptides (CPPs) that prevent the aggregation of the amyloid-β (Aβ) protein associated with Alzheimer’s disease....

Tau surpasses amyloid for predicting Alzheimer’s-associated neurodegeneration

Utilizing tau PET imaging, new research finds tau to be a more accurate indication for future neurodegeneration, highlighting its potential for precision medicine-based treatment approaches. Amyloid-β has long been the bane of every Alzheimer’s researcher. Often found in...

Ultrasound Therapy Improves the Memory of Alzheimer’s Patients

Brain stimulation therapies have emerged as viable tools to treat a variety of neurological and psychological disorders. They operate by activating or inactivating neural activity in specific regions of the brain and have...

Walking speed at age 45 linked to physical well-being, brain health

Walking speed at age 45 was associated not only with physical health but also with brain health in midlife and even early childhood, according to an NIA-supported study. The findings, published in JAMA Network Open, suggest...

High fat diet impairs new neuron creation in female mice

Sex differences in adult neurogenesis may underlie dementia risk for women. A high fat diet limits the birth and growth of new neurons in adult female, but not male, mice, according to new research published in...

Why are some people resistant to Alzheimer’s?

A new study provides insights on why some people may be more resistant to Alzheimer’s disease than others. The findings may lead to strategies to delay or prevent the condition. The study...

Microglia involved in brain plasticity during sleep

Research from the University of Rochester Medical Center (URMC) suggests that specific immune cells called microglia – which play a crucial role in reorganizing connections between nerve cells, fighting infection, and repairing damage...

Neuroimaging reveals traces of childbirth in the maternal brain

Pregnancy is one of the most dynamic periods in a woman’s life, involving a remarkable potential for brain plasticity that promotes cognitive and emotional adjustments to the newborn. A population-based neuroimaging study provides evidence for a relationship between...

Hormone Therapy Associated With Improved Cognition

A new study demonstrates the benefits of extended estrogen exposure and longer-term hormone therapy in battling cognitive decline. Estrogen has a significant role in overall brain health and cognitive function. That’s why so many...

Male and female mice have different brain cells

Caltech researchers have discovered rare brain cell types that are unique to male mice and other types that are unique to female mice. These sex-specific cells were found in a region of the brain that...

Should Scores on Mild Cognitive Impairment Tests be Adjusted for Sex?

Study Finds More Women, Fewer Men Diagnosed when Sex-specific Scoring Used  Using sex-specific scores on memory tests may change who gets diagnosed with mild cognitive impairment (MCI) by 20 percent, with possibly more women and...

Walking Speed at Early Ages Tied to Cognitive Health

Gait speed at age 45 was a marker of cognitive and physical aging, a longitudinal cohort study showed. Slow gait at age 45 was tied to accelerated biological aging across multiple organ systems and...

Young Adults’ Income Slump May Hike Risk of Middle-Aged Cognitive Issues

A new study suggests that experiencing an annual income drop of 25 percent or more during young adulthood may increase the risk of developing thinking problems and reduced brain health in middle age....

Amyloid—It’s Not Whether, but for How Long You’ve Had It

Critics of the amyloid hypothesis point out that some people with brain amyloid are cognitively fine, thank you very much. Indeed, variability in plaque burden among cognitively normal older people, combined with typically short follow-up...

Walking patterns identify specific types of dementia

Walking may be a key clinical tool in helping medics accurately identify the specific type of dementia a patient has, pioneering research has revealed. For the first time, scientists at Newcastle University have shown that people with...

MRI scans show a stronger body means a stronger brain

German researchers have found that physical fitness can actually improve brain structure and brain functioning in young people, according to a study presented at the European College of Neuropsychopharmacology (ECNP) Congress in Copenhagen. Prior research has...

Blood Pressure Around Age 40 Tied to Brain Size at Age 70

Higher and rising blood pressure in early middle age was associated with brain volume and white matter brain lesions later in life, a longitudinal study in Britain showed. High blood pressure (≥140/90 mm Hg)...

Link between brain immune cells and Alzheimer’s

Scientists from the University of California, Irvine School of Biological Sciences have discovered how to forestall Alzheimer’s disease in a laboratory setting, a finding that could one day help in devising targeted drugs that prevent...

Intensive Blood Pressure Control May Prevent Brain Damage Later in Life

The health of your heart affects the health of your brain. That’s the emerging consensus from research into how controlling blood pressure may affect brain health later in life. The latest study in this growing body of research came...

The brain’s wakefulness center is one of the earliest casualties of Alzheimer’s

Among patients with Alzheimer’s, excessive daytime napping is often observed long before memory problems are apparent. Prior research has suggested that daytime fatigue results from the poor nighttime sleep associated with Alzheimer’s, while other studies have...

Depression could signal cognitive decline in Alzheimer’s

Depressive symptoms might be an early risk factor of Alzheimer’s disease before the exhibition of cognitive deficits, a new study shows. The study, conducted at Massachusettes General Hospital (MGH), demonstrated how depressive symptoms in patients with brain...

Good heart health at age 50 linked to lower dementia risk later in life

Good cardiovascular health at age 50 is associated with a lower risk of dementia later in life, finds a study of British adults published by The BMJ today. The researchers say their findings support public health policies to improve cardiovascular...

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