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Antibiotic treatment alleviates Alzheimer’s symptoms but only in male mice

Researchers at The University of Chicago have demonstrated that the type of bacteria living in the gut can influence the development of Alzheimer’s disease symptoms in mice. The study, which will be published May 16 in the Journal...

Brain changes linked with Alzheimer’s years before symptoms appear

In a records review of 290 people at risk for Alzheimer’s disease, scientists say they have identified an average level of biological and anatomical brain changes linked to Alzheimer’s disease that occur three to 10 years...

The Germ of an Idea

The idea that infectious agents (such as viruses, bacteria, or fungi) may play a role in dementia is not new. Alois Alzheimer – the man who first described a “peculiar disease” in 1906 that would later become known as Alzheimer’s disease – first proposed that infection might be involved in the disease process. Over the years, various researchers have uncovered findings that support potential links between different infectious agents and neurological disorders.

Working Memory Changes with Age

Researchers from HSE University and York University have become the first to analyse the results of 82 functional neuroimaging studies on working memory mechanisms in different adult age groups. The meta-analyses showed...

A possible blood test for early-stage Alzheimer’s disease

A large team of researchers affiliated with a host of institutions across South Korea has developed a possible blood test to detect the early stages of Alzheimer’s disease in patients who have yet to...

Brain Zapping Technique Temporarily Reverses Memory Loss

Electromagnetic brain stimulation of an area of the brain known as the hippocampus has improved the memory of older adults with age-related memory loss, in a study published in the journal Neurology. Researchers from Northwestern...

Blood Biomarkers Plus Gene Status May Predict Cognitive Decline

Using a machine-learning approach, investigators identified four plasma proteins that correlate with cerebrospinal fluid amyloid-beta-1-42 status; these proteins plus apolipoprotein E4 genotype predicted amyloid positivity. Levels of four blood proteins, when combined with apolipoprotein...

Shorter Reproductive History Tied to Dementia Risk in Women

The timing of menopause, menarche, along with the duration of a woman’s reproductive span, was associated with the risk for dementia, according to a new analysis in the March 28 online edition of Neurology....

New PET imaging biomarker could better predict progression of Alzheimer’s

Researchers have discovered a way to better predict progression of Alzheimer’s disease. By imaging microglial activation levels with positron emission tomography (PET), researchers were able to better predict progression of the disease than with beta-amyloid PET imaging,...

Your eyes may reveal early signs of Alzheimer’s

Reduced blood capillaries in the back of the eye may be a new, noninvasive way to diagnose early cognitive impairment, the precursor to Alzheimer’s disease in which individuals become forgetful, reports a newly published Northwestern...

Scientists discover 2 rare genes linked with Alzheimer’s

Scientists have identified two rare genetic variants associated with Alzheimer’s disease. The researchers studied the DNA sequences of 5,617 people with Alzheimer’s disease, alongside 4,594 people who did not have the neurodegenerative disorder and acted...

Scientist Are Beginning To See Alzheimer’s As A Whole Body Problem

There is still no known cure for this mind wasting disease as scientists still don’t understand what causes Alzheimer’s disease, but some are starting to see the disease as a whole body problem which manifests in the...

Optimism and Healthy Aging

Mounting evidence indicates specific associations between higher levels of optimism and healthier behaviors, reduced risk of chronic diseases, and lower mortality. Yet, for public health purposes, it is critical to consider how optimism may be related to...

Depression Can Increase Stroke Risk

Depressive symptoms were tied to an increased risk of ischemic stroke, a prospective cohort study of largely Hispanic older adults found. Over 14 years of follow-up, older adults who had elevated depressive symptoms were...

Not all sleep is equal when it comes to cleaning the brain

New research shows how the depth of sleep can impact our brain’s ability to efficiently wash away waste and toxic proteins. Because sleep often becomes increasingly lighter and more disrupted as we become older, the study reinforces...

Vitamin D Deficiency Weakens Brain Scaffolding

Removing vitamin D from the diet of healthy adult mice caused a significant drop in their ability to remember and learn, which researchers said was due to a pronounced reduction in perineuronal nets in the...

Alzheimer’s May Have Different Trajectory for Women

Women developed more tau pathology than men with similar amyloid burden, an analysis of cross-sectional data found. Across two cohorts of older cognitively normal adults, women with higher amyloid burden showed higher entorhinal cortical...

New drug raises hopes of reversing memory loss in old age

An experimental drug that bolsters ailing brain cells has raised hopes of a treatment for memory loss, poor decision making and other mental impairments that often strike in old age. The drug could be taken as a...

Midlife Inflammation Tied to Steeper Memory Decline

Midlife systemic inflammation was tied to steeper late-life cognitive decline, an analysis of data from the ARIC prospective cohort showed. Adults with elevated inflammation composite scores or elevated C-reactive protein (CRP) levels during midlife...

How Exercise Improves Memory And Protects Against Alzheimer’s

For decades, the scientific consensus has been that exercise improves both mental and physical health. Numerous studies over the years have demonstrated that this is the case, but some have also found that exercise plays...

A new culprit in cognitive decline in Alzheimer’s disease

It has long been known that patients with Alzheimer’s disease have abnormalities in the vast network of blood vessels in the brain. Some of these alterations may also contribute to age-related cognitive decline in people without dementia....

Alzheimer’s May Have Different Trajectory for Women

Women developed more tau pathology than men with similar amyloid burden, an analysis of cross-sectional data found. Across two cohorts of older cognitively normal adults, women with higher amyloid burden showed higher entorhinal cortical...

Elevated BP in Young Adults Tied to Gray Matter Shrinkage

Elevated BP was tied to lower gray matter volume in young adults ages 19 t0 40, researchers found. Gray matter volumes in adults ages 20 to 30 decreased as BP increased, with changes occurring...

Psychological Distress in Midlife Linked to Future Dementia

A new Danish study suggests that vital exhaustion as a sign of psychological distress may be a risk factor for future dementia. Danish researchers found that such distress in late midlife is associated...

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