As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: January 31, 2014
by Doctor’s Lounge:
Postmenopausal women with high estradiol levels have a two-fold higher risk of developing dementia, but the risk is 14-fold higher if they also have diabetes, according to a study published online Jan. 29 in Neurology.
Laure Carcaillon, Ph.D., from the Institut National de la Santé et de la Recherche Médicale in Villejuif, France, and colleagues examined the association between blood estradiol levels and the development of dementia in postmenopausal women aged 65 years or older. Five hundred forty-three women did not develop dementia and 132 women developed dementia after four years of follow up.
Estradiol is the predominant sex hormone present in females. Estradiol, like other steroids, is derived from cholesterol. The French study didn’t focus on patients who were taking hormonal therapy. The scientists measured the level of estrogen occurring naturally in the blood of women ages 65 years and older without dementia in Bordeaux, Dijon and Montpellier, France. Four years later they were followed up and 543 women who had no dementia were compared with 132 who did. The researchers also looked at risk factors including high-blood pressure, blood clotting and other indicators of heart health.
The researchers found that the risk of dementia was significantly higher for both the lowest quartile (hazard ratio [HR], 2.4) and highest quartile (HR, 2.2) of estradiol levels after adjusting for other variables. Women with higher total estradiol levels had a significantly higher risk of dementia if they also had diabetes (HR, 14.2), compared with no diabetes (HR, 3.4). Similar results were found for bioavailable estradiol, while no association was observed for total testosterone. Adjusting for inflammatory and blood coagulation markers had no effect.
“High estradiol level is an independent predictor of incident dementia, particularly in postmenopausal women with diabetes,” Carcaillon and colleagues conclude.
For young adults with autosomal dominant Alzheimer’s disease (AD), molecular markers can identify changes associated with the disease before clinical onset, according to a study published online Feb. 12 in JAMA Neurology. Yakeel T. Quiroz, Ph.D., from Massachusetts...
Foods can determine whether someone will suffer from dementia in later years, according to researchers at the Hebrew University of Jerusalem’s Faculty of Agriculture, Food and Environment in Rehovot. A large-scale international study that...
Taking care of someone with Alzheimer’s disease and other forms of dementia is not an easy task. Caregiving is a long-term endeavour that is mentally, emotionally, physically, and financially demanding, and is a role that...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.