As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: July 19, 2014
by Alice Park for Time:
At the Alzheimer’s Association International Conference in Copenhagen, scientists described five trials that taking the unprecedented step of testing drugs that may prevent the onset of the neurodegenerative disease in people not yet experiencing cognitive decline.
The participants in the trial are all at high risk of developing Alzheimer’s either because they carry two copies of the ApoE4 gene, which is associated with a strong chance of developing the disease, or a genetic mutation that triggers the condition much earlier in life, during the 40s.
Most will be testing drugs that target amyloid, the protein that builds up in abnormal amounts in the brains of Alzheimer’s patients and triggers other damaging changes that affect memory and cognitive functions.
While other scientists reported some encouraging data on the effectiveness of diet, exercise, social support and controlling heart-related risk factors—see our piece about the lifestyle changes that prevented the disease—most experts believe that the best way to prevent Alzheimer’s may involve a combination of such lifestyle approaches with an effective drug.
Here’s the latest information on the five trials.
1. Dominantly Inherited Alzheimer Network Trial (DIAN TU)
Who is enrolled: People with a genetic mutation for Alzheimer’s disease or those who don’t know their genetic status but have a parent or sibling with Alzheimer’s-related mutations
When they should enroll: when they are cognitively normal or have mild cognitive impairment
Drugs tested: Two experimental drugs, gantenerumab and solanezumab, both of which are antibodies designed to bind to amyloid and prevent it from forming brain-damaging plaques
2. Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4)
Who is enrolled: People aged 65 to 85 years with normal thinking and memory
When they should enroll: Any time they become age eligible
Drugs tested: Solanezumab, an experimental anti-amyloid compound
Who is enrolled: Healthy seniors
When they should enroll: When they are cognitively normal or have mild cognitive impairment
Drugs tested: The trial will first pilot a screening test for two genes to see if it can accurately predict risk of mild cognitive impairment. The next phase of the trial will test an experimental compound designed to delay symptoms of mild cognitive impairment and Alzheimer’s disease in people without symptoms.
4. Alzheimer’s Prevention Initiative Autsomal Dominant Alzheimer’s Disease Treatment Trial
Who is enrolled: 300 people from a family in Columbia affected by a genetic predisposition to developing Alzheimer’s disease early in life
When they should enroll: Before symptoms begin
Drug tested: Anti-amyloid antibody crenezumab
5. Alzheimer’s Prevention Initiative APOE4 treatment Trial
Who is enrolled: people with two copies of APOE4, who are at high risk of developing Alzheimer’s disease
When they should enroll: Before cognitive symptoms of Alzheimer’s begin
Drugs tested: An immunotherapy that prompts the body’s immune system to produce antibodies against amyloid protein, and a beta-secretase inhibitor that blocks the production of certain forms of amyloid.
It is a devastating omission that may have undercut years of work by brilliant researchers from around the world. Millions of dollars and countless hours have been spent investigating dementia. But in the view of...
A stroll through the Dutch community of De Hogeweyk is a journey to what could be the future of dementia care. Located within the small town of Weesp, just outside of Amsterdam, De Hogeweyk is...
Intimate-partner violence (IPV) is a pattern of physical and/or sexual violence inflicted by an intimate or ex-intimate partner. Global estimates published by the World Health Organization indicate that about 1 in 3 women have experienced...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.