As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: August 11, 2019
by Mental Daily:
Depressive symptoms might be an early risk factor of Alzheimer’s disease before the exhibition of cognitive deficits, a new study shows.
The study, conducted at Massachusettes General Hospital (MGH), demonstrated how depressive symptoms in patients with brain amyloid deposition could impact cognitive abilities among healthy older adults. Although previous research extensively covered the connection between depression and cognitive decline, the new findings are the first to point out its influence on cortical amyloid in healthy older adults, despite minimal depressive symptoms.
As part of the study, published in JAMA Network Open, a team of researchers collected data from 276 older adults over a span of seven years, all of which participated in the Harvard Aging Brain Study. Analyzing this data led the team to the unraveling of a link between declining depressive symptoms and cognitive abilities over a span of two to seven years. The changes, consisting of brain amyloid deposition, were measured through PET imaging.
“Our research found that even modest levels of brain amyloid deposition can impact the relationship between depression symptoms and cognitive abilities. This raises the possibility that depression symptoms could be targets in clinical trials aimed at delaying the progression of Alzheimer’s disease,” said Jennifer Gatchel, lead author of the study.
“Our findings offer evidence that in healthy older adults, depression symptoms together with brain amyloid may be associated with early changes in memory and in thinking,” Gatchel added. “Depression symptoms themselves may be among the early changes in the preclinical stages of dementia syndromes. Just as importantly, these stages represent a clinical window of opportunity for closely monitoring at-risk individuals, and for potentially introducing interventions to prevent or slow cognitive decline.”
“These findings underscore the fact that depression symptoms are multi-factorial and may actually work synergistically with amyloid and related processes to affect cognition over time in older adults. This is an area we will continue to actively study,” Gatchel concluded.
As a cognitive neuroscientist and clinical neuropsychologist, I have been yammering away for years about the detrimental effects of loneliness and social isolation on brain health and overall health. Loneliness and social isolation have long been of interest to...
Scientists have collected plenty of evidence linking exercise to brain health, with some research suggesting fitness may even improve memory. But what happens during exercise to trigger these benefits? New UT Southwestern research that mapped...
A crisis has a way of highlighting problems that garner too little attention in more normal times. The pandemic has laid bare a vast array of social challenges, everything from the state of long-term care to the...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.