As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: November 15, 2015
by Meissa Glim for MD Peer Exchange:
Having a gene associated with Alzheimer’s may also mean a higher risk for depression.
The epsilon 4 allele of the apolipoprotein gene (APOE) is well known to be associated with the risk for Alzheimer’s disease, and in particular, earlier onset and more rapid progression of the disease. Whether the allele is independently associated with depression, is less clear.
Now a new study shows the allele is in fact a powerful predictor of later-life depression.
Researchers at the University of Gothenburg in Sweden followed 839 older women and men for nine years. The group members all had testing for dementia and depression at baseline and at five-year intervals. All were initially determined to be free of both. They also underwent genotyping for the APOE*E4 allele.
“In our study, the presence of the APOE epsilon 4 predicted future depression, even after excluding individuals who later developed dementia,” said Silke Kern, senior researcher in Neuropsychiatric Epidemiology at the University of Gothenburg in Gothenburg, Sweden, and corresponding author of the study. “APOE epsilon 4 might be a marker for identifying older persons at risk to develop depression or dementia, which could be important for prevention and early detection of these common disorders.”
“Late-life depression is an under-appreciated source of distress and disability in older people,” said John Krystal, editor of Biological Psychiatry in a news release “The current study suggests a new link to the biology of Alzheimer’s disease, even among people who do not show signs of memory impairment.”
The study appeared in the November 15 issue of Biological Psychiatry.
Receiving a diagnosis of Alzheimer’s disease or another type of dementia can bring mixed and complex emotions. For some, it may be a relief that there is finally an explanation for symptoms....
As a cognitive neuroscientist and clinical neuropsychologist, I have been yammering away for years about the detrimental effects of loneliness and social isolation on brain health and overall health. Loneliness and social isolation have long been of interest to...
Scientists have collected plenty of evidence linking exercise to brain health, with some research suggesting fitness may even improve memory. But what happens during exercise to trigger these benefits? New UT Southwestern research that mapped...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.