As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: May 1, 2015
by The Guardian:
Researchers at UCSD School of Medicine and an international team of scientists discovered genetic overlap between Alzheimer’s disease and two high-risk factors of cardiovascular disease. The study was published on April 10, 2015, via the scientific journal, Circulation.
The two risk factors are C-reactive protein and plasma lipids. CRP is a type of substance that increases with inflammatory reaction in a body, and plasma lipids are types of fat, mostly composed of fatty acids and cholesterol.
Scott LaFee, a scientific journalist from UCSD Health System, explained the significance of the work of the researchers.
“The key here was that they identified that the genes, [CRP and plasma lipids], have some connection with those risk factors of Alzheimer’s disease,” LaFee told the UCSD Guardian. “So the idea being that if you can control those risk factors, you can ideally slow the progression of Alzheimer’s disease.”
In the past, scientists were aware that a correlation exists between Alzheimer’s disease and cardiovascular disease. However, the relationship between the two diseases was and still is unclear. To extract further knowledge of the link between the two diseases, the researchers dug into minor details of examining specific genetic signals.
According to the article published in Circulation, the researchers engaged in a statistical investigation and found out that the overlap associated with Alzheimer’s disease, CRP and the three components of total cholesterol in single nucleotide polymorphisms enriches AD SNPs, which increases the risk of developing Alzheimer’s disease. SNPs refer to the most common genetic variations in human body.
“Using summary statistics from genome-wide association studies of over 200,000 individuals, we investigated overlap in single nucleotide polymorphisms associated with clinically diagnosed Alzheimer’s disease and C-reactive protein, triglycerides, high- and low-density lipoprotein levels,” the researchers reported. “We found up to 50-fold enrichment of Alzheimer’s disease SNPs for different levels of association with CRP, LDL, HDL and TG-SNPs.”
The contemporary treatments for Alzheimer’s disease are not capable of fully controlling the symptoms of the disease. On the other hand, the treatments for cardiovascular disease are relatively much more effective, and the link between the two diseases may open a new pathway to Alzheimer’s disease’s effective treatment.
“This finding suggests that here you have two risk factors for cardiovascular disease, which are more controllable; you can lower cholesterol, you can lower blood lipids and inflammatory protein,” LaFee said. “And that may have an impact on prospects of people getting Alzheimer’s disease.”
Ole A. Andreassen, senior co-author of the research, spoke about the importance of potential success in finding an effective treatment.
“Currently, there are no disease-modifying therapies, and much attention has been focused upon prevention and early diagnosis,” Andreassen said to UCSD Health System. “Delaying dementia onset by even just two years could potentially lower the worldwide prevalence of Alzheimer’s disease by more than 22 million cases over the next four decades, resulting in significant societal savings.”
Alzheimer’s disease is a neurological disorder that degenerates memory and cognition. Some of its symptoms include loss of memory, impaired speaking and writing and change in personality and behavior. In the U.S., more than 5 million people suffer from the disease, most of the patients being over the age of 65.
Research has shown music can stimulate your brain, keep it engaged as you age, and help with memory. It’s a total brain workout!
Memory loss and cognitive decline are commonly thought to be the earliest signs of the disorder, but a new study has found declines in glucose levels in the brain come even sooner. Even better? The same team...
by G.S. Mudur for The Telegraph Ashwagandha, a plant used for centuries in Ayurvedic medicine, cleaned out abnormal protein deposits in the brain and reversed damage and behavioural changes observed in Alzheimer’s disease when tested on mice, a team of...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.