As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: April 5, 2015
by Jeffrey Craven for Healio:
A systematic review of risk factors for developing dementia after mild cognitive impairment found that factors like managing diabetes, prediabetes and neurospychiatric symptoms may help modify the risk for developing dementia.
“The findings of this systematic review suggest that managing diabetes and components of the metabolic syndrome and dietary interventions are logical targets for future trials,” Claudia Cooper, PhD, MRCPsych, of the division of psychiatry, University College of London and the department of psychiatry and behavioral sciences, Johns Hopkins Bayview Medical Center, Baltimore, and colleagues wrote in the study.
The researchers evaluated 76 epidemiological and clinical studies. They found that in 10 studies of patients with insulin-dependent or non–insulin-dependent diabetes, the unadjusted pooled OR for developing dementia after mild cognitive impairment was 1.65 (95% CI, 1.12-2.43).
In 13 higher quality epidemiological and 18 clinical studies, the researchers found patients with amnestic mild cognitive impairment and diabetes were at an increased risk of developing Alzheimer’s. Specifically, they found diabetes was a risk factor for developing dementia from any-type and amnestic mild cognitive impairment (pooled OR = 1.65; 95% CI, 1.12 to 2.43).
In an epidemiological study, the researchers found that treating diabetes lowered the risk factor for developing dementia, while a clinical study showed patients with diabetes or prediabetes with a fasting glucose of greater than 100 mg/dL with any-type mild cognitive impairment had a higher risk of developing Alzheimer’s dementia. Metabolic syndrome and prediabetes were predictive factors of developing Alzheimer’s dementia for patients with mild cognitive impairment in one study. A single, higher quality epidemiological study showed a Mediterranean diet was associated with a decreased risk of developing Alzheimer’s dementia.
In addition, neuropsychiatric symptoms were significantly associated with developing all-cause dementia or Alzheimer’s dementia in four clinical studies (pooled OR = 3.11, 95% CI, 1.38-7.02). Depression was a predictor of all-cause dementia developing from any-type mild cognitive impairment in epidemiological, but not clinical studies, while higher serum folate levels were a predictor in one epidemiological and one clinical study.
A new comprehensive study from Florida State University (FSU) finds no evidence to support the idea that personality changes begin before the clinical onset of mild cognitive impairment (MCI) or dementia. MCI is an intermediate...
On the evening of Monday November 27th, join us for conversation and cocktails with award-winning journalist, editor and author Tina Brown, and Indigo’s CEO Heather Reisman. Hear from Tina Brown about her eight-year tenure at Vanity...
The presence of TAR DNA-binding protein 43 (TDP-43) in the hippocampus on postmortem examination is associated with increased rates of hippocampal atrophy in patients with Alzheimer’s disease (AD), new research suggests. This association was greatest...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.