Published on: November 27, 2016
by Jodelle Maglaya for Health Imaging:
Contrast enhanced MRI found leakages in the blood-brain barrier of people with early Alzheimer’s disease (AD) is associated with cognitive decline.
The study published in Radiology tested 16 patients with early AD and 17 healthy age-matched controls who underwent dynamic contrast material enhanced MRI. The researchers used the Paltak graphical approach to measure blood-brain barrier rate and volume.
Data suggested that the blood-brain barrier leakage rate in images were much higher in patients with AD compared to those without the disease, showing up most in the cerebrum. Patients with AD also had a significantly higher volume of leaking brain tissue in the gray matter, normal-appearing white matter and deep gray matter.
“Blood-brain barrier leakage means that the brain has lost its protective means, the stability of brain cells is disrupted and the environment in which nerve cells interact becomes ill-conditioned,” said study author Walter H. Backes, PhD, from the Maastricht University Medical Center in Maastricht, Netherlands. “These mechanisms could eventually lead to dysfunction in the brain.”
The correlation between blood-brain barrier impairment and decline in cognitive performance that the researchers found, suggests that a leak in the blood-brain barrier is part of the early stages of AD and could eventually lead to cognitive decline and dementia.
“For Alzheimer’s research, this means that a novel tool has become available to study the contribution of blood-brain barrier impairment in the brain to disease onset and progression in early stages or pre-stages of dementia,” said Backes.
Thanks to the ongoing support of our partner Brain Canada, and The Citrine Foundation of Canada, Women’s Brain Health Initiative’s newest edition of MIND OVER MATTER has just been published. Loaded with interesting science-based articles, MIND OVER...
On December 2nd, in celebration of Women’s Brain Health Day, join thousands of others and take part in the Stand Ahead® Memory Challenge to stand up against research bias and stand ahead for women’s brain...
YOU’RE INVITED! On December 2nd, the second annual Women’s Brain Health Day, take the memory challenge and help us combat brain-aging diseases that disproportionately affect women. Join CTV’s Pattie Lovett-Reid and Anne-Marie Mediwake, along...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.