As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: February 18, 2015
by Neurology Advisor:
Researchers from Sweden may have uncovered a link between Alzheimer’s and type 2 diabetes through research on amyloidosis, backing up research that claims patients with type 2 diabetes have a near two-fold greater risk of developing Alzheimer’s disease.
The formation of fibril deposits occurs in both Alzheimer’s and type 2 diabetes (T2D), however new research suggests that amyloid formation in the brain may stimulate the growth of fibrils in the murine pancreas. Additionally, pancreatic-related amyloid can be found along human brain senile plaques.
Focusing on how amyloid deposits spread within a tissue or from organ to organ, researchers injected transgenic mice that expressed humam islet amyloid polypeptide (IAPP) with preformed fibrils of synthetic IAPP, proIAPP, or beta-amyloid. After 10 months, the number of islets with amyloid was significantly higher compared to controls of all three types of fibrils. Additionally, the amyloid consisted of IAPP across all groups, and no amyloid deposits were found in the spleen, kidney, liver, heart, or lungs.
Researchers then analyzed human tissue from the pancreas and brain, and found that sections of pancreas with islet amyloid in patients with T2D had no beta-amyloid immunoreactivity, while all samples were immunoreactive for IAPP. Researchers also analyzed samples of the temporal cortex from patients with Alzheimer’s and compared them to patients with frontotemporal dementia, progressive supranuclear palsy, or no neurologic disease. IAPP reactivity was found in all samples, and those from Alzheimer’s patients had 1.4 times higher concentrations of IAPP than non-Alzheimer’s patients.
While researchers aren’t yet clear on how or if IAPP is produced or derived from pancreatic beta-cells, cross-seeding by amyloid aggregates may be a possible mechanism for the initiation of amyloid formation.
It is a devastating omission that may have undercut years of work by brilliant researchers from around the world. Millions of dollars and countless hours have been spent investigating dementia. But in the view of...
A stroll through the Dutch community of De Hogeweyk is a journey to what could be the future of dementia care. Located within the small town of Weesp, just outside of Amsterdam, De Hogeweyk is...
Intimate-partner violence (IPV) is a pattern of physical and/or sexual violence inflicted by an intimate or ex-intimate partner. Global estimates published by the World Health Organization indicate that about 1 in 3 women have experienced...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.