As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: December 21, 2018
by Marjorie S. Miller for Penn State:
Negative mood — such as sadness and anger — is associated with higher levels of inflammation and may be a signal of poor health, according to researchers at Penn State.
The investigators found that negative mood measured multiple times a day over time is associated with higher levels of inflammatory biomarkers. This extends prior research showing that clinical depression and hostility are associated with higher inflammation.
Inflammation is part of the body’s immune response to such things as infections, wounds, and damage to tissues. Chronic inflammation can contribute to numerous diseases and conditions, including cardiovascular disease, diabetes and some cancers.
This study, the results of which were recently published in the journal Brain, Behavior, and Immunity, is what the researchers believe is the first examination of associations between both momentary and recalled measures of mood or affect with measures of inflammation, according to principal investigator Jennifer Graham-Engeland, associate professor of biobehavioral health at Penn State.
Participants were asked to recall their feelings over a period time in addition to reporting how they were feeling in the moment, in daily life. These self-assessments were taken over a two-week period, then each was followed by a blood draw to measure markers that indicated inflammation.
The researchers found that negative mood accumulated from the week closer to the blood draw was associated with higher levels of inflammation.
Additional analyses also suggested that the timing of mood measurement relative to the blood draw mattered, Graham-Engeland said. Specifically, there were stronger trends of association between momentary negative affect and inflammation when negative mood was assessed closer in time to blood collection.
This work is novel because researchers not only used questionnaires that asked participants to recall their feelings over a period time, they also asked participants how they were feeling in the moment, Graham-Engeland said.
In addition, momentary positive mood from the same week was associated with lower levels of inflammation, but only among men in this study.
Participants were from a community sample generated from a housing development in the Bronx, New York, as part of the larger Effects of Stress on Cognitive Aging, Physiology, and Emotion (ESCAPE) study. Participants were socio-economically, racially and ethnically diverse.
The research was cross-sectional, Graham-Engeland said, and several analyses were exploratory and will require replication. These results inspire ongoing research to investigate how intervention in daily life can improve mood and help individuals cope with stress.
“We hope that this research will prompt investigators to include momentary measures of stress and affect in research examining inflammation, to replicate the current findings and help characterize the mechanisms underlying associations between affect and inflammation,” Graham-Engeland said. “Because affect is modifiable, we are excited about these findings and hope that they will spur additional research to understand the connection between affect and inflammation, which in turn may promote novel psychosocial interventions that promote health broadly and help break a cycle that can lead to chronic inflammation, disability, and disease.”
As a cognitive neuroscientist and clinical neuropsychologist, I have been yammering away for years about the detrimental effects of loneliness and social isolation on brain health and overall health. Loneliness and social isolation have long been of interest to...
Scientists have collected plenty of evidence linking exercise to brain health, with some research suggesting fitness may even improve memory. But what happens during exercise to trigger these benefits? New UT Southwestern research that mapped...
A crisis has a way of highlighting problems that garner too little attention in more normal times. The pandemic has laid bare a vast array of social challenges, everything from the state of long-term care to the...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.