As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: July 20, 2013
by Charles Bankhead for MedPage Today:
People who consider themselves physically inactive have an increased risk of stroke, adding to previous evidence of the association, results of a large cohort study showed.
Self-reported low activity was associated with a 20% increase in stroke risk, as compared with people who reported higher levels of physical activity, according to Michelle N. McDonnell, PhD, of the University of South Australia in Adelaide, and co-authors.
Adjustment for traditional stroke risk factors reduced the impact of physical activity to 14% excess risk, which was no longer statistically significant, they reported online in Stroke.
“Any effect of physical activity is likely to be mediated through reducing traditional risk factors,” the authors wrote.
Physical inactivity trails only hypertension as a contributor to stroke risk, having an estimated population-attributable risk of 28.5%. Whether precise amounts or type of activity influences stroke risk has been unclear, the authors noted in their introduction.
Meta-analyses have suggested that regular physical activity reduces stroke risk by 25% to 30% as compared with little or no activity. Recent evidence has pointed toward differences in the impact of physical activity on stroke risk by sex, the authors added.
In an effort to clarify the association between physical activity and stroke, McDonnell and colleagues analyzed data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national, multiracial prospective cohort study.
The analysis comprised 30,239 REGARDS participants ≥45, including oversampling in the Stroke Belt region of the southeastern U.S.
Baseline data collection included self-reported physical activity, defined as the weekly frequency of activity sufficiently intense to cause sweating. Physical activity could include leisure, commuting, and occupational activities.
On the basis of the activity frequency, investigators separated the participants into three groups: 1=no activity, 2=one to three times per week, and 3=four or more times weekly.
During a mean follow-up of 5.7 years, investigators documented 918 incidents of stroke and transient ischemic attack. After adjustment for age, sex, race, and interaction between age and race, a significant association between physical activity and stroke emerges.
Comparison of the lowest and highest frequencies of physical activity produced a hazard ratio of 1.20 (95% CI 1.01-1.42). Self-reported frequency of one to three times weekly was associated with a hazard ratio of 1.14, which did not achieve statistical significance (95% CI 0.96-1.35).
After adjustment for other stroke risk factors (diabetes, hypertension, body mass index, alcohol consumption, and smoking), the hazard declined by 30% to 1.14 and was no longer significant (95% CI 0.95-1.37, P=0.17).
Investigators also compared the highest frequency of physical activity with a weekly frequency of zero to three. The analysis produced an adjusted hazard ratio of 1.18 for stroke for the lower frequency (95% CI 1.01-1.36). Adjustment for region, urban/rural residence, and socioeconomic status attenuated the association and made it no longer significant (HR 1.17, 95% CI 0.99-1.36).
Analysis by stroke type (ischemic versus hemorrhagic) did not appreciably alter the results.
Separate analyses of men and women showed a significant association between frequency of physical activity and stroke risk among men (HR 1.26 to HR 1.30) but not women.
For young adults with autosomal dominant Alzheimer’s disease (AD), molecular markers can identify changes associated with the disease before clinical onset, according to a study published online Feb. 12 in JAMA Neurology. Yakeel T. Quiroz, Ph.D., from Massachusetts...
Foods can determine whether someone will suffer from dementia in later years, according to researchers at the Hebrew University of Jerusalem’s Faculty of Agriculture, Food and Environment in Rehovot. A large-scale international study that...
Taking care of someone with Alzheimer’s disease and other forms of dementia is not an easy task. Caregiving is a long-term endeavour that is mentally, emotionally, physically, and financially demanding, and is a role that...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.