As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: June 11, 2012
by Tod Neale for MedPage Today:
Passively monitoring how quickly an individual walks in the home may provide clues about the development of mild cognitive impairment, researchers suggested.
Older individuals with mild cognitive impairment were more likely than their cognitively intact counterparts to walk slowly instead of at a moderate or fast speed, according to Hiroko Dodge, PhD, of Oregon Health & Science University in Portland, and colleagues.
In addition, mild cognitive impairment was associated with variations in walking speed, the researchers reported in the June 12 issue of Neurology.
“Although we found a difference in decline in walking speed between the nonamnestic mild cognitive impairment and cognitively intact groups, further in-home studies will be required to translate this finding to clinically relevant ways of identifying those who may develop mild cognitive impairment prospectively,” the authors wrote.
The study included individuals 70 and older (mean age 84) who were living independently and who participated in the Intelligent Systems for Assessing Aging Change (ISAAC) cohort study. The homes of all of the participants were fitted with passive infrared sensors to measure walking speed.
At baseline, there were 54 participants with intact cognition, 31 with nonamnestic mild cognitive impairment, and eight with amnestic mild cognitive impairment. The researchers focused on the individuals with nonamnestic impairment because the sample size was large enough for comparisons. Follow-up lasted 2.6 years.
The researchers defined three groups based on mean walking speed — slow, moderate, and fast. The moderate and fast groups had slight declines in walking speed during the study, whereas the slow group had a more noticeable reduction.
The individuals with nonamnestic mild cognitive impairment were about 9 times more likely to be in the slow group than in the fast and about 5 times more likely to be in the slow group than in the moderate group (P=0.01 for both).
The participants with nonamnestic mild cognitive impairment made up 16.7% of the fast group, 34.6% of the moderate group, and 66.7% of the slow group.
In addition to walking speed, the researchers also used walking speed variability to define groups. The magnitude of walking speed variability was expressed as the coefficient of variation.
Group 1 was characterized by the highest baseline variability, followed by an increase in variability and then sharply declining coefficient of variation. Groups 2 and 3 had relatively stable coefficients of variation during the study and group 4 had the lowest baseline coefficient of variability with a decline over time.
Individuals with nonamnestic mild cognitive impairment were more likely to be in either group 1 or 4, “possibly representing the trajectory of walking speed variability for early- and late-stage mild cognitive impairment, respectively,” according to the authors.
“At the early stage of disease, subjects may begin to develop increasing variability in clinical outcomes such as day-by-day fluctuations in walking speed, balance, functional abilities, mood, or cognitive performance,” they explained. “This phase of increasing variability would be the result of physiologic or functional reserve trying to compensate for the dysfunction associated with the disease.”
“However,” they continued, “once compensatory systems fail or pathologic burdens go beyond the level sustainable by reserve, the variability or short-term fluctuation diminishes because biologic systems lose their ability to preserve premorbid function.”
The researchers acknowledged that the study was limited by the focus on nonamnestic mild cognitive impairment and the nonrandom selection of participants.
A new comprehensive study from Florida State University (FSU) finds no evidence to support the idea that personality changes begin before the clinical onset of mild cognitive impairment (MCI) or dementia. MCI is an intermediate...
On the evening of Monday November 27th, join us for conversation and cocktails with award-winning journalist, editor and author Tina Brown, and Indigo’s CEO Heather Reisman. Hear from Tina Brown about her eight-year tenure at Vanity...
The presence of TAR DNA-binding protein 43 (TDP-43) in the hippocampus on postmortem examination is associated with increased rates of hippocampal atrophy in patients with Alzheimer’s disease (AD), new research suggests. This association was greatest...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.