As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: November 5, 2015
by Jayalakshmi K for International Business Times:
Alzheimer’s disease could actually be a collection of diseases that should be treated with a variety of different approaches. Distinct disorders that eventually lead to neurodegeneration need to be classified and treated separately, suggest researchers at the Hebrew University of Jerusalem’s Faculty of Medicine.
Prion disorders like Alzheimer’s and Parkinsons result from a protein-folding gone amiss. This has been noticed to appear sporadically or as an inherited mutation-linked disorder. In the former, the appearance of symptoms is later.
The researchers were looking into some aspects of the mutation-linked diseases like the similar time frames of apparently distinct disorders. And why the symptoms only begin to show late in life.
The international research team was led by professor Ehud Cohen and Dr Tziona Ben-Gedalya at The Institute for Medical Research Israel – Canada (IMRIC) in the Hebrew University’s Faculty of Medicine.
Since neurodegenerative disorders arise from aberrant protein folding, the team postulated that age probably affects the activity of proteins needed to help other proteins fold properly.
They found that the development of Alzheimer’s disease in certain families, and of a familial prion disorder in other families, both originate from malfunction of the protein “cyclophilin B”.
However, the mechanism leading to Alzheimer’s disease in individuals with these mutations is different to that of the disease’s emergence in patients with other mutations.
According to professor Ehud Cohen: “This study provides important new insights: first, it shows that the development of distinct neurodegenerative disorders stems from a similar mechanism. More importantly, it indicates that Alzheimer’s disease can emanate from more than one mechanism, suggesting that it is actually a collection of diseases that should be classified.”
Cohen blames the lack of an efficient therapy on the clubbing together of patients with distinct disorders. It is essential to carefully characterise and classify the mechanisms that underlie Alzheimer’s disease, in order to allow for the development of novel therapies that can be prescribed to the individual patient according to their relevant disease sub-type, he says.
Alzheimer’s affects millions of people around the world. In 2010, there were between 21 and 35 million people worldwide with the disease.
Research has pointed to a continued build up of misfolded proteins leading to plaque and a tangle in the brain, as a result of which brain cells die. Blocking the pathways to this brain cell death has been the focus of drug development. However, most drugs tested on animals have shown up undesired side-effects.
Interestingly, in 2014 scientists at Washington university had found that schizophrenia is a combination of eight distinct disorders linked to gene mutations with their own separate symptoms.
It has long been known that vitamin D – often referred to as the “sunshine vitamin” – is one of the most essential vitamins for our overall health because it regulates calcium in the body...
SWEAT IT OUT Sauna bathing, a form of passive heat therapy, is a traditional activity in Finland that is primarily used for relaxation purposes and is becoming increasingly common in many other populations. The typical...
Has anyone ever suggested that you take a deep breath to help you relax when you are feeling anxious or stressed? That advice has roots in the wisdom of ancient yogic teachings. Breathing – that...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.