As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: February 6, 2012
by Dr. Loretta Lanphier for Restless Boomers
Swedish researchers have discovered that the lower your brain levels of tocotrienols and tocopherols (the entire family of vitamin E) the higher the chance that you will experience mild cognitive impairment or Alzheimer’s disease.
The study led by Mangialasche, F. and colleagues from Karolinska Institute in Stockholm, Sweden discovered that among study participants, high serum levels of vitamin E were associated with approximately a 50 percent reduction in the risk of Alzheimer’s disease. The Swedish researchers analyzed the vitamin E status in 168 people with Alzheimer’s, 166 people with mild cognitive impairment, and 187 cognitively normal people.
The blood samples from the subjects, who were dementia-free at baseline, were analyzed to determine plasma levels of vitamin E (alpha-, beta-, gamma, and delta-tocopherol; alpha-, beta-, gamma-, and delta-tocotrienol). The subjects were then followed up for 6 years to record any incidents of Alzheimer’s disease. The risk of Alzheimer’s disease was reduced by 45 percent among participants who had their total tocopherols in the highest tertile, 54 percent among those whose total tocotrienols were in the highest tertile and 45 percent in those who had their total vitamin E in the highest tertile, compared to those in the lowest tertile.
According to another study, Georgia Health Sciences University researchers report in the journal Nature Communications that full-spectrum vitamin E helps repair tears in the plasma membranes that protect cells from outside forces and screen what enters and exits. Vitamin E appears to aid repair in several ways. As an antioxidant, it helps eliminate destructive byproducts from the body’s use of oxygen that impede repair. Because it’s lipid-soluble, vitamin E can actually insert itself into the membrane to prevent free radicals from attacking. It also can help keep phospholipids, a major membrane component, compliant so they can better repair after a tear.
Vitamin E includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential neuroprotective activity. α-Tocopherol has mainly been investigated in relation to cognitive impairment. We examined the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer’s disease (AD).
Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopherylquinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people.
Compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD.
For young adults with autosomal dominant Alzheimer’s disease (AD), molecular markers can identify changes associated with the disease before clinical onset, according to a study published online Feb. 12 in JAMA Neurology. Yakeel T. Quiroz, Ph.D., from Massachusetts...
Foods can determine whether someone will suffer from dementia in later years, according to researchers at the Hebrew University of Jerusalem’s Faculty of Agriculture, Food and Environment in Rehovot. A large-scale international study that...
Taking care of someone with Alzheimer’s disease and other forms of dementia is not an easy task. Caregiving is a long-term endeavour that is mentally, emotionally, physically, and financially demanding, and is a role that...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.