As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: October 16, 2012
by Sky News:
A nanotechnology nasal spray is being developed that could transform the early detection and treatment of Alzheimer’s.
The device shoots tiny magnetic particles into the nose which enter the bloodstream and are carried to the brain. Each particle is fused to an antibody that targets and binds to rogue molecules believed to play an early role in the disease.
Magnetic resonance imaging (MRI) can detect both the particles and the molecules.
To date scientists have only tested the technique in the laboratory on human brain tissue cultures. But if it can be shown to work in human patients it could lead to a major leap forward in managing Alzheimer’s.
Scientists believe the changes that lead to Alzheimer’s begin decades before the first symptoms appear.
By the time a patient is diagnosed the disease is already far advanced, and experts suspect that is the main reason why a number of promising drugs have failed in patient trials. Identifying the disease much earlier could make it far easier to treat.
Details of the new research were presented at the annual meeting of the Society for Neuroscience in New Orleans, US.
Lead scientist William Klein, from Northwestern University, Chicago, said: “We have created a probe that targets a unique marker of Alzheimer’s disease. This technology is a promising tool for early AD diagnosis and for evaluating the efficacy of investigational new drugs at early stages of the disease.”
The antibodies developed by Klein’s team target amyloid beta oligomers, small molecules that appear early in the disease and may be responsible for initiating Alzheimer’s memory loss.
Large clumps of amyloid beta protein in the brain are a key feature of late stage Alzheimer’s.
Laboratory experiments showed that it was possible to distinguish healthy and diseased brain tissue using the antibodies.
Attaching the antibodies to magnetic nanoparticles allows them to be tracked by an MRI scan.
The scientists are now working on incorporating the particles into a nasal spray.
Two powerful tools for early Alzheimer’s detection may fit in the palm of your hand. In fact, according to new research based on data from the Framingham Heart Study, one of those tools is your...
The physical benefits of swimming are obvious in athletes like 23-time Olympic gold medalist Michael Phelps. Toned muscles, muscle strength, and a well-sculpted physique describe a “swimmer’s body.” However, there is one characteristic most swimmers possess that we can’t see...
“I just can’t imagine what you’re going through.” It’s not...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.