As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: February 1, 2017
by Science Daily:
Memory loss and cognitive decline are commonly thought to be the earliest signs of the disorder, but a new study has found declines in glucose levels in the brain come even sooner. Even better? The same team also believes they have figured out a way to stop these levels from falling in the first place, a finding that could potentially prevent Alzheimer’s.
Although doctors have long noted the association between declining glucose levels in the brain and the onset of Alzheimer’s disease, for the first time ever, a study now published online in the journal Translational Psychiatry has proved that these declining energy levels are a direct trigger for the cognitive impairments traditionally associated with the disease. According to a recent statement on the study, this may explain why diabetes, a condition in which glucose cannot enter the cells, is a known risk factor for dementia. According to the study, a protein known as p38 may be able to prevent this deprivation from occurring.
“The findings are very exciting,” explained lead researcher Dr. Domenico Praticò in a statement. “There is now a lot of evidence to suggest that p38 is involved in the development of Alzheimer’s disease.”
For the study, the team purposely deprived the brains of mice of glucose in order to observe the result. As expected, these mice exhibited signs of decline to suggest that neural communication pathways in their brains had broken down. What’s more, the glucose-deprived mice performed significantly worse than control mice in maze memory tests. These mice also displayed high levels of phosphorylated tau and dramatically increased amounts of cell death in the brains, two other well known indications of Alzheimer’s onset.
The study also identified p38 as a possible candidate for the development of a drug to prevent the onset of cognitive decline caused by low glucose levels. According to the research, this protein is naturally made in the body as a response to glucose deprivation. Future research will further investigate p38’s role in memory impairments.
Preventing Alzheimer’s disease is a major goal for scientists around the world, and this year there have been several breakthroughs in this effort. For example, this July a team from Flinders University in Adelaide Australia in partnership with a research team at the Institute of Molecular Medicine, and University of California, Irvine released their efforts on creating a drug that could prevent brain protein buildup, the main hallmark of the disease. According to the research, these findings could lead to a vaccine against Alzheimer’s in as little as five years.
Along the same vein, researchers from Baylor College of Medicine, Texas Children’s Hospital and Johns Hopkins University School of Medicine are hoping to create a pill that when taken could prevent the accumulation of toxic molecules in the brain that eventually go on to form these brain plaques.
The number of older people, including those living with dementia, is rising, as younger age mortality declines. However, the age-specific incidence of dementia has fallen in many countries, probably because of improvements in education, nutrition, health...
Among HIV-negative people, studies have found that loneliness can interfere with mental health, cognitive functioning and quality of life. In this population, one analysis has found that persistent loneliness is associated with a...
Researchers believe game-changing test will be available to doctors in two years. A simple blood test may be able to tell you whether you have Alzheimer’s disease and, in some cases, it can detect the...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.