As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: March 25, 2016
by Deccan Chronicle:
A new blood test may potentially help detect Alzheimer’s disease at an early stage, giving people up to 15 years warning before the symptoms appear, scientists say.
The test is based on an immuno-chemical analysis using an infrared sensor. The sensor’s surface is coated with highly specific antibodies which extract biomarkers for Alzheimer’s from the blood or the cerebrospinal fluid, taken from the lower part of the back (lumbar liquor), researchers said.
The infrared sensor analyses if the biomarkers show already pathological changes, which can take place more than 15 years before any clinical symptoms appear, they said.
A major problem of Alzheimer’s disease diagnosis is the fact that, by the time the first clinical symptoms appear, massive irreversible damage to the brain has already occurred.
At that point, symptomatic treatment is the only available option, researchers said.
“If we wish to have a drug at our disposal that can significantly inhibit the progress of the disease, we need blood tests that detect Alzheimer’s in its pre-dementia stages,” said Klaus Gerwert from Ruhr-University Bochum in Germany.
For the novel test, the secondary structure of the so-called Amyloid beta peptides serves as biomarker. This structure changes in Alzheimer’s patients, researchers said.
In the misfolded, pathological structure, more and more Amyloid beta peptides can accumulate, gradually forming visible plaque deposits in the brain that are typical for Alzheimer’s disease. This happens more than 15 years before first clinical symptoms appear, they said.
The pathological beta Amyloid plaques can be temporarily detected by positron emission tomography (Amyloid PET) but this procedure is comparatively expensive and is accompanied by radiation exposure, they said.
Together with researchers from German Centre for Neurogenerative Diseases (DZNE), Gerwert and colleagues developed an infrared sensor for detecting misfolding of Amyloid beta peptides.
The infrared sensor extracts the Amyloid beta peptide from body fluids. After initially working with cerebrospinal fluid, the researchers subsequently expanded the method towards blood analysis.
“We do not merely select one single possible folding arrangement of the peptide; rather, we detect how all existing Amyloid beta secondary structures are distributed, in their healthy and in their pathological forms,” said Gerwert. Researchers analysed samples from 141 patients.
They achieved a diagnostic precision of 84 per cent in the blood and 90 per cent in cerebrospinal fluid, compared with the clinical gold standard.
The test showed an increase of misfolded biomarkers as spectral shift of Amyloid beta band below threshold, thus diagnosing Alzheimer’s, researchers said.
The findings were published in the journal Biophotonics.
USC researchers have discovered a secret sauce in the brain’s vascular system that preserves the neurons needed to keep dementia and other diseases at bay. The finding, in a mouse model of the human...
Ask anyone what worries them most about getting older, and more than a few people will say losing the ability to remember things is high up on their list. After a lifetime of making memories and forging...
A study out of the University of Nottingham in the United Kingdom found that there is a link between dementia and certain classes of anticholinergic drugs. The drugs, particularly antidepressants, bladder antimuscarinics, antipsychotics and antiepileptic drugs,...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.