As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: December 1, 2015
by Lynne Terry for the Oregonian:
A gene linked to both breast and ovarian cancer also appears to play a role in Alzheimer’s, a new study shows.
Researchers in California found that people who died from Alzheimer’s or even suffered cognitive decline had low levels of the BRCA1 gene. They also found a similar depletion of the gene in mice genetically engineered to develop Alzheimer’s. BRCA1 plays a key role in repairing broken strands of DNA, a molecule that carries our genetic code.
Mutant forms of BRCA1 are linked to both breast and ovarian cancer.
“It is extremely interesting that one molecule can be critically involved in two apparently opposing conditions: cancer, in which too many cells are born and neurodegenerative disease, in which too many brain cells die off,” Dr. Lennart Mucke, director of the Gladstone Institute of Neurological Disease, San Francisco, told the National Institute of Health.
The study, published in Nature Communications, found that BRCA1 plays a critical role in repairing DNA in central neurons and that reductions of the protein were associated with cellular dysfunction and cognitive decline. Autopsies showed that people who had Alzheimer’s or even mild cognitive impairment had lower levels of BRCA1 in their brain than people who did not have those conditions. Those lower levels were associated with a build-up of amyloid beta, a key component in the plaque that clogs the brains of Alzheimer’s patients.
The researchers said their study raises questions about whether mutations in BRCA1 associated with breast and ovarian cancer also affects the protein in the brain. They also said that BRCA1 may have other functions besides DNA repair.
“Additional studies are needed to address these possibilities and explore the therapeutic potential of enhancing DNA repair in Alzheimer’s disease and related conditions,” the study said.
A large team of researchers affiliated with a host of institutions across South Korea has developed a possible blood test to detect the early stages of Alzheimer’s disease in patients who have yet to...
Electromagnetic brain stimulation of an area of the brain known as the hippocampus has improved the memory of older adults with age-related memory loss, in a study published in the journal Neurology. Researchers from Northwestern...
Telling an elderly parent that they need to stop driving and taking away their car keys is one of the most difficult things adult children have to do. But there is something that can be...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.