Published on: July 25, 2016
Certain gene variants are known to raise a person’s risk of Alzheimer’s disease. But a new study finds that even in people carrying this DNA, factors such as gender and physical or mental activity can affect that risk.
The study tracked dementia rates for 642 people aged 53 to 95 at the start of the study. All carried at least one of two types of DNA linked to higher Alzheimer’s disease risk: the APOEe4 or CLU CC gene variants.
Carrying the APOEe4 variant “confers a risk of developing Alzheimer’s disease of up to 10 to 14 times compared to that of non-carriers,” explained Dr. Luca Giliberto, who reviewed the new findings.
He’s an investigator in Alzheimer’s disease at the Feinstein Institute for Medical Research in Manhasset, N.Y.
But Giliberto stressed that “having a [genetic] risk factor does not mean you will get the disease.” And that’s what the new study found — especially for people with certain characteristics.
Led by Kirstie McDermott, of the University of Alberta in Edmonton, Canada, the researchers tracked the Alzheimer’s gene carriers for nine years.
The study found that gender appeared to matter. While about 47 percent of men showed signs of decline in their memory level and stability over the study period, that number was approximately 32 percent for women.
This “memory resilience” over time was also found to be improved for both sexes in people who had higher education, better muscle tone, or who engaged in “challenging, everyday” intellectual activities, such as playing bridge, for example.
For women, specifically, having healthy lungs, a good walking speed and an active social life — things such as volunteering and visiting family and friends — were also linked to maintaining a healthy memory, the study found.
One factor seemed specific to men in keeping dementia at bay: Avoiding depression.
Giliberto wasn’t surprised by the findings.
“Conducting an active lifestyle, higher education and physical activity are all reasonable predictors of better aging,” he said. “Thus, it is not surprising that their effect would also be evident in carriers of genetic risk for Alzheimer’s disease.”
Dr. Ezriel Kornel directs the Neurosciences, Orthopedic and Spine Institute at Northern Westchester Hospital in Mount Kisco, N.Y.
“What all of this means, in a nutshell, is that if you take care of yourself physically, mentally and participate in your community, you are more likely to maintain a well-functioning memory,” even if you carry Alzheimer’s-linked DNA, Kornel said.
The findings were to be presented Sunday at the Alzheimer’s Association’s International Conference in Toronto. Findings presented at medical meetings are typically considered preliminary until published in a peer-reviewed journal.
Thanks to the ongoing support of our partner Brain Canada, and The Citrine Foundation of Canada, Women’s Brain Health Initiative’s newest edition of MIND OVER MATTER has just been published. Loaded with interesting science-based articles, MIND OVER...
On December 2nd, in celebration of Women’s Brain Health Day, join thousands of others and take part in the Stand Ahead® Memory Challenge to stand up against research bias and stand ahead for women’s brain...
YOU’RE INVITED! On December 2nd, the second annual Women’s Brain Health Day, take the memory challenge and help us combat brain-aging diseases that disproportionately affect women. Join CTV’s Pattie Lovett-Reid and Anne-Marie Mediwake, along...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.