As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: July 23, 2015
by Steve Ford for Nursing Times:
Latest research data has provided the first hints that amyloid therapies may slow down the progression of Alzheimer’s disease.
Antibodies that clear amyloid plaques from the brains of people with Alzheimer’s disease may be the first therapy to demonstrate slowing of cognitive decline, according to research presented today.
Findings from industry studies of three alternative antibody therapies were presented at the Alzheimer’s Association International conference in Washington.
Interim results from a safety study of aducanumab in people with very early stage Alzheimer’s disease show that the drug reduced the amount of the amyloid plaques in the brain, with an increasing effect as the dose was increased.
Although the study is only designed to test safety, a dose-dependent reduction in cognitive impairment was observed.
However, over a quarter of people on the higher doses of the drug, which is being developed by Biogen, experienced headaches and a third to a half experienced abnormalities on a brain scan.
Meanwhile, long-term analysis of the Ely Lilly drug solanezumab – in the EXTENSION EXT study – reported that people with mild Alzheimer’s disease who have taken the drug for 3.5 years showed some benefits in cognition, compared to those who have only taken it for two years.
In addition, results from the Scarlet RoAd trial of ganterenerumab in people at very early stages of Alzheimer’s disease suggested the drug was able to reduce amyloid in the brain and that a higher dose may be required to see any clinical effect.
However, the trial was terminated earlier this year by Roche, as it was considered unlikely to find any significant effect on cognition.
Dr Doug Brown, head of research at the Alzheimer’s Society, said that after a decade of no new therapies for dementia the new study results were “an exciting step forward”.
The trial findings “strongly” suggested that targeting people in the earliest stages of Alzheimer’s with antibody treatments was the “best way to slow or stop” the disease, he said.
“These drugs are able to reduce the sticky plaques of amyloid that build up in the brain, and now we have seen the first hints that doing this early enough may slow disease progression,” said Dr Brown.
“We will have to wait for the ongoing trials to finish to know the full risks and benefits of these drugs,” he said. “If they are positive, these drugs will be the first identified to directly interfere with the disease process and slow the progression of Alzheimer’s.”
Speaking specifically on aducanumab, Dr Brown noted that the drug was “not without side effects”, which might be “unacceptable to some”.
“We look forward to seeing whether this truly is an effective treatment when the current trial ends in a few years,” he said.
On solanezumab, he said it was “good news” that some patients had been receiving the antibody for over three years with beneficial effects.
“The current trial has finished recruiting participants, so in just 18 months we may get an exciting first look at the final results,” he said.
Join us for conversation and reception with 8-time Juno Award winning Singer-Songwriter & Actress Jann Arden, along with Your Morning Host Anne-Marie Mediwake. Whether she is captivating audiences with her heartfelt music, entertaining them with...
Chronic pain can impact everything from your mood, to your sleep to your social life. “The first things we lose are fun activities and leisure and we end up only doing what we...
A team of researchers, led by NYU Abu Dhabi Assistant Professor of Biology Mazin Magzoub, has developed small proteins called cell-penetrating peptides (CPPs) that prevent the aggregation of the amyloid-β (Aβ) protein associated with Alzheimer’s disease....
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.