Published on: April 27, 2017
by Brian Ellis for Neurology Advisor:
In a cohort of non-demented elderly patients, excessive daytime sleepiness (EDS) increased the rate of β-amyloid accumulation, according to results presented at the 2017 American Academy of Neurology Annual Meeting.
“We found that elderly subjects with [EDS] at baseline accumulated more β-amyloid in their brains, particularly in vulnerable areas,” study investigator Diego Z. Carvalho, MD, of the Mayo Clinic in Rochester, Minnesota, told Neurology Advisor. “The results confirmed our expectations, based on prior studies showing that these individuals are at increased risk for dementia. We were able to show that this risk may, at least to some extent, be secondary to more β-amyloid accumulation.”
According to Dr Carvalho, the aim of the study was to better understand the association between aging and increased daytime sleepiness, since the latter is linked to functional impairment, falls, and cognitive decline in the elderly. “We wanted to understand what is behind the cognitive decline seen in [the] elderly with [EDS] in prior studies,” Dr. Carvalho said. “Is it related to Alzheimer’s disease?”
For the study, researchers enrolled 283 non-demented individuals (age ≥70) who had at least 2 serial Pittsburgh Compound-B positron emission tomography (PiB-PET) scans and had completed sleep questionnaires. Researchers defined EDS as an Epworth Sleepiness Scale score ≥10.
According to study methodology, multiple linear regression models were fit in 6 Alzheimer’s disease-related regions — orbitofrontal, prefrontal, anterior cingulate, cingulate-precuneus, temporal, and parietal — to examine if baseline EDS predicted variability in amyloid accumulation between 2 serial scans.
In addition, researchers controlled for baseline age, sex, apolipoprotein E, education, regional PiB positivity (standard uptake value ratio, ≥1.4), physical activity, cardiovascular comorbidities, reduced sleep duration, respiratory symptoms during sleep, depression, and interval between scans.
Results revealed a significant association between baseline EDS and increased β-amyloid accumulation in the orbitofrontal, anterior cingulate, and cingulate/precuneus regions, although the strength of the association was greater in PiB-positive areas.
In subset analysis, EDS increased β-amyloid accumulation in the anterior cingulate (0.06; 95% CI, 0.02-0.1; P =.007), cingulate/precuneus (0.076; 95% CI, 0.03-0.12; P =.002), and parietal cortex (0.058; 95% CI, 0.01-0.11; P =.03) in patients who were amyloid positive at baseline in these regions.
“Elderly subjects with [EDS] are more vulnerable to Alzheimer’s disease pathology,” Dr Carvalho concluded. “Identifying and treating sleep disorders underlying [EDS] in this population may halt or slow down the progression to dementia.”
Dr Carvalho added that it remains unclear why EDS is associated with more amyloid accumulation.
“Sleep disorders, especially [obstructive sleep apnea], may certainly play a role,” he said. “However, [EDS] may also be an early marker of degeneration of brain areas that promotes wakefulness, especially the locus coeruleus, which is involved early in Alzheimer’s disease.”
While anyone can experience a stroke at any age, women experience more stroke events than men and are less likely to recover. “BE FAST” is a checklist of 6 items to keep in mind when assessing whether you might be...
Enjoy these highlights from our Engaging Millennial Minds Chew on This virtual event with celebrity chef Mark McEwan.
This virtual culinary event featured Celebrity Chef and Restauranteur Mark McEwan.
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.