Increased Midlife Triglyceride Levels Predictive of Alzheimer Disease Pathology

by Sheila Jacobs for Neurology Advisor:Increased triglyceride levels at midlife are predictive of the presence of β-amyloid (Aβ) and tau pathologies 20 years later in cognitively healthy individuals, according to the results of a recent longitudinal cohort study published in Neurology.The current study sought to assess the impact of midlife lipid levels on Alzheimer disease (AD) brain pathology 20 years later in cognitively normal elderly individuals. A total of 318 participants with data available on fasting lipid levels at midlife (mean age, 54 years) were enrolled in the analysis. The presence of Aβ and tau pathologies 20 years later (mean age, 73 years) was identified by quantifying AD biomarkers in cerebrospinal fluid (CSF). In a subpopulation of 134 individuals, brain Aβ was also measured via positron emission tomography (PET) scans.CSF Aβ₄₂ and Aβ PET revealed the presence of Aβ in approximately 20% of the cognitively healthy population. The CSF Aβ₄₂/phosphorylated tau (p-tau) ratio demonstrated both Aβ and tau pathologies in 16% of the healthy individuals.Higher levels of triglycerides in midlife were significantly associated with abnormal CSF Aβ₄₂ (odds ratio [OR] 1.34; 95% CI, 1.03-1.75; P =.029) and with abnormal Aβ₄₂/p-tau ratio (OR 1.46; 95% CI, 1.10-1.93; P =.009), after adjusting for age, sex, APOE ε4 status, education, and vascular risk factors. Triglycerides were also associated with abnormal Aβ PET scans in multivariable regression models (P =.013 and P =.025, based on the model evaluated), but the association was somewhat decreased in the fully adjusted model.Source: http://www.neurologyadvisor.com/neurodegenerative-diseases/high-triglycerides-amyloid-tau-pathology/article/734407/