As the largest resource of information specific to women's brain health, we are sure you will find what you are looking for, and promise that you will discover new information.
Published on: July 24, 2016
by Business Standard:
Warding off Alzheimer’s disease could one day be as easy as popping antibiotics, suggests a new study.
In the University of Chicago study, long-term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer’s disease, and activated inflammatory microglial cells in the brains of mice.
The study also showed significant changes in the gut microbiome after antibiotic treatment, suggesting the composition and diversity of bacteria in the gut play an important role in regulating immune system activity that impacts progression of Alzheimer’s disease.
“We’re exploring very new territory in how the gut influences brain health,” said senior author Sangram Sisodia, adding: “This is an area that people who work with neurodegenerative diseases are going to be increasingly interested in, because it could have an influence down the road on treatments.”
Two of the key features of Alzheimer’s disease are the development of amyloidosis, accumulation of amyloid-Beta (ABeta) peptides in the brain, and inflammation of the microglia, brain cells that perform immune system functions in the central nervous system. Buildup of ABeta into plaques plays a central role in the onset of Alzheimer’s, while the severity of neuro-inflammation is believed to influence the rate of cognitive decline from the disease.
For this study, Sisodia and his team administered high doses of broad-spectrum antibiotics to mice over five to six months. At the end of this period, genetic analysis of gut bacteria from the antibiotic-treated mice showed that while the total mass of microbes present was roughly the same as in controls, the diversity of the community changed dramatically.
The antibiotic-treated mice also showed more than a two-fold decrease in ABeta plaques compared to controls, and a significant elevation in the inflammatory state of microglia in the brain. Levels of important signaling chemicals circulating in the blood were also elevated in the treated mice.
Sisodia cautioned, “There’s probably not going to be a cure for Alzheimer’s disease for several generations, because we know there are changes occurring in the brain and central nervous system 15 to 20 years before clinical onset,” adding: “We have to find ways to intervene when a patient starts showing clinical signs, and if we learn how changes in gut bacteria affect onset or progression, or how the molecules they produce interact with the nervous system, we could use that to create a new kind of personalized medicine.”
The study is published in Scientific Reports.
A large team of researchers affiliated with a host of institutions across South Korea has developed a possible blood test to detect the early stages of Alzheimer’s disease in patients who have yet to...
Electromagnetic brain stimulation of an area of the brain known as the hippocampus has improved the memory of older adults with age-related memory loss, in a study published in the journal Neurology. Researchers from Northwestern...
Telling an elderly parent that they need to stop driving and taking away their car keys is one of the most difficult things adult children have to do. But there is something that can be...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.