Published on: September 16, 2017
by Erica Rheinschild for Medical XPress:
Researchers at the Keck School of Medicine of USC are tackling the sixth-leading cause of death in the United States—Alzheimer’s disease—with a new study that intervenes decades before the disease develops.
The school is joining approximately 90 institutions in North America, Europe and Australia in the Generation Study, which is testing a vaccine and oral medication to prevent or delay Alzheimer’s in older adults at increased risk for developing the disease. More than 70 USC researchers across a range of disciplines are dedicated to the prevention, treatment and potential cure of Alzheimer’s.
By focusing on prevention, the study is taking a different approach to halting a disease that affects 47 million people worldwide.
“One of the challenges in developing new medications for Alzheimer’s is that researchers tend to test medications on people with more advanced Alzheimer’s, and the medications are simply not proving to be effective,” Lon Schneider, the study’s lead investigator. “By intervening 10 to 12 years before Alzheimer’s manifests, we may be able to stop it before it begins or delay the symptoms.”
Adults 60 to 75 years of age with normal cognition who are interested in participating must undergo genetic testing for the apolipoprotein e4 (APOE4) gene, which is associated with an increased risk of developing Alzheimer’s.
About half of people with Alzheimer’s disease carry the APOE4 gene, which can be inherited from either parent, said Schneider, professor of psychiatry and the behavioral sciences and professor of neurology. About 25 percent of the population carries one copy of the APOE4 gene, and about 2 to 3 percent of the population carries two copies, having received one from each parent. To qualify for the study, participants must have two copies of the gene.
Delay the disease
Qualifying participants may randomly receive either a vaccine, oral medication, placebo vaccine or placebo oral medication. Both the vaccine and oral medication target amyloid beta—the main component in amyloid plaques in the brain and a culprit in Alzheimer’s—in two different ways: The vaccine helps the body develop antibodies against amyloid beta, while the oral medication blocks an enzyme that creates amyloid beta. Participants may receive the study medications for five to eight years.
“If we are able to show that the vaccine or oral medication is effective at delaying Alzheimer’s among people at higher risk, then this would strongly imply that we are on the right track for developing treatments,” Schneider said. “If we can delay the onset of Alzheimer’s by five years, for example, the incidence of the illness would drop by half. It would also give individuals five more years without symptoms of the illness.”
Should the vaccine or oral medication prove to be effective in people with two copies of the APOE4 gene, then it would likely also be effective for other people at risk for Alzheimer’s, according to Schneider.
“Our clinician-scientists have been actively involved in clinical drug development for Alzheimer’s diseasefor more than 30 years,” said Rohit Varma, dean of the Keck School of Medicine. “This study is a reflection of our continued efforts to conquer one of the greatest health challenges of our time.”
For information about how to participate in the study, contact Nadine Diaz at (323) 442-7600 or email@example.com.
On Mother’s Day, amazing support for women’s brain health and our initiative from Robin Wright, Diane Lane, Trudie Styler, Teddy Sears, Martha Stewart, Tonya Lewis Lee, Marcia Gay Harden, Donna Karan, and Cecile Richards.
Here’s some of the “Best Brain Boosts” we’ve discovered to help women boost their brain health, providing a buffer against cognitive decline.
Thanks to the ongoing support of our partner Brain Canada, and The Citrine Foundation of Canada, Women’s Brain Health Initiative’s newest edition of MIND OVER MATTER has just been published. Loaded with interesting science-based articles, MIND OVER...
The material presented through the Think Tank feature on this website is in no way intended to replace professional medical care or attention by a qualified practitioner. WBHI strongly advises all questioners and viewers using this feature with health problems to consult a qualified physician, especially before starting any treatment. The materials provided on this website cannot and should not be used as a basis for diagnosis or choice of treatment. The materials are not exhaustive and cannot always respect all the most recent research in all areas of medicine.